Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

Elevated blood CXCL10/IP-10 levels during primary HIV-1 infection (PHI) were described as an independent marker of rapid disease onset, more robust than peak viremia or CD4 cell nadir. IP-10 enhances the recruitment of CXCR3+ cells, which include major HIV-target cells, raising the question if it pr...

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發表在:PLoS Pathog
Main Authors: Ploquin, Mickaël J., Madec, Yoann, Casrouge, Armanda, Huot, Nicolas, Passaes, Caroline, Lécuroux, Camille, Essat, Asma, Boufassa, Faroudy, Jacquelin, Béatrice, Jochems, Simon P., Petitjean, Gaël, Angin, Mathieu, Gärtner, Kathleen, Garcia-Tellez, Thalía, Noël, Nicolas, Booiman, Thijs, Boeser-Nunnink, Brigitte D., Roques, Pierre, Saez-Cirion, Asier, Vaslin, Bruno, Dereudre-Bosquet, Nathalie, Barré-Sinoussi, Françoise, Ghislain, Mathilde, Rouzioux, Christine, Lambotte, Olivier, Albert, Matthew L., Goujard, Cécile, Kootstra, Neeltje, Meyer, Laurence, Müller-Trutwin, Michaela C.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980058/
https://ncbi.nlm.nih.gov/pubmed/27509048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005774
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