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Total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity
The first total synthesis of leopolic acid A, a fungal metabolite with a rare 2,3-pyrrolidinedione nucleus linked to an ureido dipeptide, was designed and carried out. Crucial steps for the strategy include a Dieckmann cyclization to obtain the 2,3-pyrrolidinedione ring and a Wittig olefination to i...
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| Publicado no: | Beilstein J Org Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979754/ https://ncbi.nlm.nih.gov/pubmed/27559415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.12.159 |
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