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The Global Self-Reactivity Profile of the Natural Antibody Repertoire Is Largely Independent of Germline D(H) Sequence

Natural antibodies (NAbs) are produced in the absence of exogenous antigenic stimulation and circulate in the blood of normal, healthy individuals. These antibodies have been shown to provide one of the first lines of defense against both bacterial and viral pathogens. Conservation of the NAb repert...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Vale, Andre M., Cavazzoni, Cecília B., Nobrega, Alberto, Schroeder, Harry W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979587/
https://ncbi.nlm.nih.gov/pubmed/27559334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00296
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