Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis

Homeostasis of the gastrointestinal (GI) tract is controlled by complex interactions between epithelial and immune cells and the resident microbiota. Here, we studied the role of Wnt signaling in GI homeostasis using Disheveled 1 knockout (Dvl1(–/–)) mice, which display an increase in whole gut tran...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Belinson, Haim, Savage, Adam K., Fadrosh, Douglas, Kuo, Yien-Ming, Lin, Din, Valladares, Ricardo, Nusse, Ysbrand, Wynshaw-Boris, Anthony, Lynch, Susan V., Locksley, Richard M., Klein, Ophir D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979554/
https://ncbi.nlm.nih.gov/pubmed/27525310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85395
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