Disclosing Pleiotropic Effects during Genetic Risk Assessment for Alzheimer’s Disease: A Randomized, Controlled Trial

BACKGROUND: Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information. OBJECTIVE: To determine the safety and behavioral impact of disclosing modest associations between APOE genotype and coronary artery disease (CAD) risk during APOE-b...

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Detalhes bibliográficos
Publicado no:Ann Intern Med
Main Authors: Christensen, Kurt D., Roberts, J. Scott, Whitehouse, Peter J., Royal, Charmaine D. M., Obisesan, Thomas O., Cupples, L. Adrienne, Vernarelli, Jacqueline A., Bhatt, Deepak L., Linnenbringer, Erin, Butson, Melissa B., Fasaye, Grace-Ann, Uhlmann, Wendy R., Hiraki, Susan, Wang, Na, Cook-Deegan, Robert, Green, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979546/
https://ncbi.nlm.nih.gov/pubmed/26810768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7326/M15-0187
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