Disclosing Pleiotropic Effects during Genetic Risk Assessment for Alzheimer’s Disease: A Randomized, Controlled Trial

BACKGROUND: Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information. OBJECTIVE: To determine the safety and behavioral impact of disclosing modest associations between APOE genotype and coronary artery disease (CAD) risk during APOE-b...

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Dades bibliogràfiques
Publicat a:Ann Intern Med
Autors principals: Christensen, Kurt D., Roberts, J. Scott, Whitehouse, Peter J., Royal, Charmaine D. M., Obisesan, Thomas O., Cupples, L. Adrienne, Vernarelli, Jacqueline A., Bhatt, Deepak L., Linnenbringer, Erin, Butson, Melissa B., Fasaye, Grace-Ann, Uhlmann, Wendy R., Hiraki, Susan, Wang, Na, Cook-Deegan, Robert, Green, Robert C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979546/
https://ncbi.nlm.nih.gov/pubmed/26810768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7326/M15-0187
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