NGF sensitizes TrkA SH-SY5Y neuroblastoma cells to TRAIL-induced apoptosis

We report a novel pro-apoptotic function for nerve growth factor (NGF) and its tropomyosin-related kinase A (TrkA) receptor in sensitizing TRAIL (TNF-related apoptotis-inducing ligand)-resistant SH-SY5Y neuroblastoma (NB) cells to TRAIL-induced apoptosis, resulting in the abrogation of anchorage-ind...

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Veröffentlicht in:Cell Death Discov
Hauptverfasser: Ruggeri, P, Cappabianca, L, Farina, A R, Gneo, L, Mackay, A R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979468/
https://ncbi.nlm.nih.gov/pubmed/27551499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.4
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