Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis

Apoptosis culminates in secondary necrosis due to lack of ATP. Cancer stem cells form spheres after apoptosis by evoking the blebbishield emergency program. Hence, determining how blebbishields avoid secondary necrosis is crucial. Here we demonstrate that N-Myc and VEGFR2 control transformation from...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Jinesh, GG, Molina, JR, Huang, L, Laing, NM, Mills, GB, Bar-Eli, M, Kamat, AM
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979437/
https://ncbi.nlm.nih.gov/pubmed/27551498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.3
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