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Graded Foxo1 Activity in Regulatory T Cells Differentiates Tumor Immunity from Autoimmunity
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a pivotal role in maintaining immunological self-tolerance(1-5); yet, excessive Treg cell activities suppress anti-tumor immune responses(6-8). Compared to resting phenotype Treg (rTreg) cells in the secondary lymphoid organs,...
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| Publicado en: | Nature |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4978705/ https://ncbi.nlm.nih.gov/pubmed/26789248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16486 |
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