Nicotinamide Adenine Dinucleotide Phosphate Oxidase–Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension

Estrogen and oxidative stress have been implicated in pulmonary arterial hypertension (PAH). Mechanisms linking these systems are elusive. We hypothesized that estrogen metabolite, 16α-hydroxyestrone (16αOHE1), stimulates nicotinamide adenine dinucleotide phosphate oxidase (Nox)–induced reactive oxy...

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Publicado en:Hypertension
Autores principales: Hood, Katie Y., Montezano, Augusto C., Harvey, Adam P., Nilsen, Margaret, MacLean, Margaret R., Touyz, Rhian M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott, Williams & Wilkins 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978604/
https://ncbi.nlm.nih.gov/pubmed/27402919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07668
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