Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

Despite years of plasma HIV-RNA levels <40 copies per milliliter during combination antiretroviral therapy (cART), the majority of HIV-infected patients exhibit persistent seropositivity to HIV-1 and evidence of immune activation. These patients also show persistence of proviruses of HIV-1 in cir...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Imamichi, Hiromi, Dewar, Robin L., Adelsberger, Joseph W., Rehm, Catherine A., O’Doherty, Una, Paxinos, Ellen E., Fauci, Anthony S., Lane, H. Clifford
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978246/
https://ncbi.nlm.nih.gov/pubmed/27432972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609057113
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