Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy

Evidence suggests that the glycogen synthase kinase 3 (GSK3)–dictated nuclear exclusion and degradation of Nrf2 is pivotal in switching off the self-protective antioxidant stress response after injury. Here, we examined the mechanisms underlying this regulation in glomerular disease. In primary podo...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Zhou, Sijie, Wang, Pei, Qiao, Yingjin, Ge, Yan, Wang, Yingzi, Quan, Songxia, Yao, Ricky, Zhuang, Shougang, Wang, Li Juan, Du, Yong, Liu, Zhangsuo, Gong, Rujun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2016
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978041/
https://ncbi.nlm.nih.gov/pubmed/26647425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050565
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