Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

BACKGROUND: Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of loss of Fragile X Mental Retardation Protein (FMRP), but recent work has shown...

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Vydáno v:Neural Dev
Hlavní autoři: Truszkowski, Torrey L. S., James, Eric J., Hasan, Mashfiq, Wishard, Tyler J., Liu, Zhenyu, Pratt, Kara G., Cline, Hollis T., Aizenman, Carlos D.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977860/
https://ncbi.nlm.nih.gov/pubmed/27503008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13064-016-0069-7
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