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Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay

Drug repositioning has been attracting increasingly attention for its advantages of reducing costs and risks. Statistics showed that around one quarter of the marketed drugs are organohalogens. However, no study has been reported, to the best of our knowledge, to aim at efficiently repositioning org...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Yisu, Guo, Binbin, Xu, Zhijian, Li, Bo, Cai, Tingting, Zhang, Xinben, Yu, Yuqi, Wang, Heyao, Shi, Jiye, Zhu, Weiliang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977465/
https://ncbi.nlm.nih.gov/pubmed/27501852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31074
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