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Transport of digoxin-loaded polymeric nanoparticles across BeWo cells, an in vitro model of human placental trophoblast

BACKGROUND: Fetal arrhythmias can lead to fetal congestive heart failure and hydrops fetalis. Digoxin (the first-line treatment) has low transplacental permeability and high risk of maternal side effects. Biodegradable digoxin-loaded PEGylated poly(lactic-co-glycolic acid) nanoparticles may increase...

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Bibliographische Detailangaben
Veröffentlicht in:Ther Deliv
Hauptverfasser: Albekairi, Norah A, Al-Enazy, Sanaalarab, Ali, Shariq, Rytting, Erik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Science Ltd 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976999/
https://ncbi.nlm.nih.gov/pubmed/26652279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/tde.15.79
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