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Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

Glial cells efficiently recognize and clear cellular debris after nervous system injury to maintain brain homeostasis, but pathways governing glial responses to neural injury remain poorly defined. We identify the Drosophila guanine-nucleotide exchange factor (GEF) complex Crk/Mbc/dCed-12, and the s...

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Pubblicato in:Nat Neurosci
Autori principali: Ziegenfuss, Jennifer S., Doherty, Johnna, Freeman, Marc R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976689/
https://ncbi.nlm.nih.gov/pubmed/22706267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3135
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