Miniaturizing VEGF: Peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response

The angiogenic properties of VEGF are mediated through the binding of VEGF to its receptor VEGFR2. The VEGF/VEGFR interface is constituted by a discontinuous binding region distributed on both VEGF monomers. We attempted to reproduce this discontinuous binding site by covalently linking into a singl...

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Veröffentlicht in:Sci Rep
Hauptverfasser: De Rosa, Lucia, Finetti, Federica, Diana, Donatella, Di Stasi, Rossella, Auriemma, Sara, Romanelli, Alessandra, Fattorusso, Roberto, Ziche, Marina, Morbidelli, Lucia, D’Andrea, Luca Domenico
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976335/
https://ncbi.nlm.nih.gov/pubmed/27498819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31295
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