A subpopulation of high IL-21-producing CD4(+) T cells in Peyer’s Patches is induced by the microbiota and regulates germinal centers

The production of IL-21 by T follicular helper (Tfh) cells is vital in driving the germinal centre reaction and high affinity antibody formation. However, the degree of Tfh cell heterogeneity and function is not fully understood. We used a novel IL-21eGFP reporter mouse strain to analyze the diversi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jones, Leigh, Ho, Wen Qi, Ying, Sze, Ramakrishna, Lakshmi, Srinivasan, Kandhadayar G., Yurieva, Marina, Ng, Wan Pei, Subramaniam, Sharrada, Hamadee, Nur H., Joseph, Sabrina, Dolpady, Jayashree, Atarashi, Koji, Honda, Kenya, Zolezzi, Francesca, Poidinger, Michael, Lafaille, Juan J., Curotto de Lafaille, Maria A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976330/
https://ncbi.nlm.nih.gov/pubmed/27499025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30784
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