Hirschsprung disease is associated with an L286P mutation in the fifth transmembrane domain of the endothelin-B receptor in the N-ethyl-N-nitrosourea-induced mutant line

Hirschsprung disease (HSCR), or colonic aganglionosis, is a congenital disorder characterized by the absence of intramural ganglia along variable lengths of the colon, resulting in intestinal obstruction. It is the most common cause of congenital intestinal obstruction, with an incidence of 1 in 5,0...

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Bibliographic Details
Published in:Exp Anim
Main Authors: Chen, Bing, Ouyang, Hui-Ling, Wang, Wen-Hua, Yin, Yi-Heng, Yan, Lin-Na, Yang, Bin, Xue, Zheng-Feng
Format: Artigo
Language:Inglês
Published: Japanese Association for Laboratory Animal Science 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976238/
https://ncbi.nlm.nih.gov/pubmed/26923755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.15-0110
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