DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy

Methylation at 5-cytosine (5-mC) is a fundamental epigenetic DNA modification associated recently with cardiac disease. In contrast, the role of 5-hydroxymethylcytosine (5-hmC)—5-mC's oxidation product—in cardiac biology and disease is unknown. Here we assess the hydroxymethylome in embryonic,...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Greco, Carolina M., Kunderfranco, Paolo, Rubino, Marcello, Larcher, Veronica, Carullo, Pierluigi, Anselmo, Achille, Kurz, Kerstin, Carell, Thomas, Angius, Andrea, Latronico, Michael V. G., Papait, Roberto, Condorelli, Gianluigi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976219/
https://ncbi.nlm.nih.gov/pubmed/27489048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12418
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