Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model

AIM: To examine the effects of the endothelin type A receptor antagonist ambrisentan on hepatic steatosis and fibrosis in a steatohepatitis mouse model. METHODS: Fatty liver shionogi (FLS) FLS-ob/ob mice (male, 12 wk old) received ambrisentan (2.5 mg/kg orally per day; n = 8) or water as a control (...

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Bibliografiske detaljer
Udgivet i:World J Hepatol
Main Authors: Okamoto, Toshiaki, Koda, Masahiko, Miyoshi, Kennichi, Onoyama, Takumi, Kishina, Manabu, Matono, Tomomitsu, Sugihara, Takaaki, Hosho, Keiko, Okano, Junichi, Isomoto, Hajime, Murawaki, Yoshikazu
Format: Artigo
Sprog:Inglês
Udgivet: Baishideng Publishing Group Inc 2016
Fag:
Basic Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976212/
https://ncbi.nlm.nih.gov/pubmed/27574547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4254/wjh.v8.i22.933
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