Mutations in TSC1, TSC2, and MTOR are associated with response to rapalogs in patients with metastatic Renal Cell Carcinoma

PURPOSE: We examined the hypothesis that mutations in mTOR pathway genes are associated with response to rapalogs in metastatic renal cell carcinoma (mRCC). EXPERIMENTAL DESIGN: We studied a cohort of mRCC patients who were treated with mTOR inhibitors with distinct clinical outcomes. Tumor DNA from...

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Publicado no:Clin Cancer Res
Main Authors: Kwiatkowski, David J., Choueiri, Toni K., Fay, André P., Rini, Brian I., Thorner, Aaron R., de Velasco, Guillermo, Tyburczy, Magdalena E., Hamieh, Lana, Albiges, Laurence, Agarwal, Neeraj, Ho, Thai H., Song, Jiaxi, Pignon, Jean-Christophe, Barrios, Pablo M., Michaelson, M. Dror, Van Allen, Eliezer, Krajewski, Katherine M., Porta, Camillo, Pal, Sumanta, Bellmunt, Joaquim, McDermott, David F., Heng, Daniel Y. C., Gray, Kathryn P., Signoretti, Sabina
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976069/
https://ncbi.nlm.nih.gov/pubmed/26831717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2631
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