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“Smart” (129)Xe NMR Biosensor for pH-Dependent Cancer Cell Labeling
Here we present a “smart” xenon-129 NMR biosensor that undergoes a peptide conformational change and labels cancer cells at acidic pH. To a cryptophane host molecule with high Xe affinity, we conjugated a 30mer EALA-repeat peptide that is alpha-helical at pH 5.5 and disordered at pH 7.5. The (129)Xe...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976068/ https://ncbi.nlm.nih.gov/pubmed/25848822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01938 |
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