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Molecular profile of tumor-specific CD8+ T cell hypofunction in a transplantable murine cancer model()
Mechanisms of self-tolerance often result in CD8+ tumor-infiltrating lymphocytes (TIL) with a hypofunctional phenotype incapable of tumor clearance. Using a transplantable colon carcinoma model, we found that CD8+ T cells became tolerized in less than 24 hours in an established tumor environment. To...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4976021/ https://ncbi.nlm.nih.gov/pubmed/27371726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600589 |
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