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Expression of MicroRNA-34a in Alzheimer’s Disease Brain Targets Genes Linked to Synaptic Plasticity, Energy Metabolism, and Resting State Network Activity

Polygenetic risk factors and reduced expression of many genes in late-onset Alzheimer’s disease (AD) impedes identification of a target(s) for disease-modifying therapies. We identified a single microRNA, miR-34a that is over expressed in specific brain regions of AD patients as well as in the 3xTg-...

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Detalhes bibliográficos
Publicado no:Brain Res
Main Authors: Sarkar, S., Jun, S., Rellick, S., Quintana, D.D., Cavendish, J.Z., Simpkins, J. W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975975/
https://ncbi.nlm.nih.gov/pubmed/27235866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2016.05.026
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