T-cell epitope conservation across allergen species is a major determinant of immunogenicity

BACKGROUND: Patients with pollen allergies are frequently poly-sensitized. Pollen contain epitopes that are conserved across multiple species. OBJECTIVE: Demostrate that cross-reactive T-cells which recognize conserved epitopes show higher levels of expansion than T-cells recognizing monospecific ep...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Westernberg, Luise, Schulten, Véronique, Greenbaum, Jason A, Natali, Sara, Tripple, Victoria, McKinney, Denise M., Frazier, April, Hofer, Heidi, Wallner, Michael, Sallusto, Federica, Sette, Alessandro, Peters, Bjoern
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975972/
https://ncbi.nlm.nih.gov/pubmed/26883464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.11.034
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