Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease

Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall bioge...

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Detalhes bibliográficos
Publicado no:Microbes Infect
Main Authors: Van Laar, Tricia A., Hole, Camaron, Karna, S.L. Rajasekhar, Miller, Christine L., Reddick, Robert, Wormley, Floyd L., Seshu, J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975942/
https://ncbi.nlm.nih.gov/pubmed/26993029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.micinf.2016.03.004
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