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Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease
Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall bioge...
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Publicado no: | Microbes Infect |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4975942/ https://ncbi.nlm.nih.gov/pubmed/26993029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.micinf.2016.03.004 |
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