Concurrent nuclear ERG and MYC protein overexpression defines a subset of locally advanced prostate cancer: potential opportunities for synergistic targeted therapeutics

BACKGROUND: Recurrent ERG gene fusions, the most common genetic alterations in prostate cancer, drive overexpression of the nuclear transcription factor ERG and are early clonal events in prostate cancer progression. The nuclear transcription factor MYC is also frequently overexpressed in prostate c...

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Veröffentlicht in:Prostate
Hauptverfasser: Udager, Aaron M., De Marzo, Angelo M., Shi, Yang, Hicks, Jessica L., Cao, Xuhong, Siddiqui, Javed, Jiang, Hui, Chinnaiyan, Arul M., Mehra, Rohit
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975940/
https://ncbi.nlm.nih.gov/pubmed/27159573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.23175
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