DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes

Leptin is a key regulator of energy intake and expenditure. This peptide hormone is expressed in mouse white adipose tissue, but hardly expressed in 3T3-L1 adipocytes. Using bisulfite sequencing, we found that CpG islands in the leptin promoter are highly methylated in 3T3-L1cells. 5-azacytidine, an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kuroda, Masashi, Tominaga, Ayako, Nakagawa, Kasumi, Nishiguchi, Misa, Sebe, Mayu, Miyatake, Yumiko, Kitamura, Tadahiro, Tsutsumi, Rie, Harada, Nagakatsu, Nakaya, Yutaka, Sakaue, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975473/
https://ncbi.nlm.nih.gov/pubmed/27494408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160532
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados