Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

A neuroprotective role of autophagy mediates the degradation of β-amyloid peptide (Aβ) in Alzheimer’s disease (AD). The previous study showed cilostazol modulates autophagy by increasing beclin1, Atg5 and LC3-II expressions, and depletes intracellular Aβ accumulation. This study elucidated the mecha...

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Pubblicato in:PLoS One
Autori principali: Park, So Youn, Lee, Hye Rin, Lee, Won Suk, Shin, Hwa Kyoung, Kim, Hye Young, Hong, Ki Whan, Kim, Chi Dae
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975437/
https://ncbi.nlm.nih.gov/pubmed/27494711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160620
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