Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor

BACKGROUND: We comprehensively analyzed X-ray cocrystal structures of dipeptidyl peptidase IV (DPP-4) and its inhibitor to clarify whether DPP-4 alters its general or partial structure according to the inhibitor used and whether DPP-4 has a common rule for inhibitor binding. RESULTS: All the main an...

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Detalhes bibliográficos
Publicado no:BMC Struct Biol
Main Authors: Nojima, Hiroyuki, Kanou, Kazuhiko, Terashi, Genki, Takeda-Shitaka, Mayuko, Inoue, Gaku, Atsuda, Koichiro, Itoh, Chihiro, Iguchi, Chie, Matsubara, Hajime
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974693/
https://ncbi.nlm.nih.gov/pubmed/27491540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-016-0062-8
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