Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors

BRAF inhibitors are highly effective therapies for the treatment of BRAF(V600)-mutated melanoma, with the main toxicity being a variety of hyperproliferative skin conditions due to paradoxical activation of the mitogen-activated protein kinase (MAPK) pathway in BRAF wild-type cells. Most of these hy...

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Pubblicato in:Nat Commun
Autori principali: Escuin-Ordinas, Helena, Li, Shuoran, Xie, Michael W., Sun, Lu, Hugo, Willy, Huang, Rong Rong, Jiao, Jing, de-Faria, Felipe Meira, Realegeno, Susan, Krystofinski, Paige, Azhdam, Ariel, Komenan, Sara Marie D., Atefi, Mohammad, Comin-Anduix, Begoña, Pellegrini, Matteo, Cochran, Alistair J., Modlin, Robert L., Herschman, Harvey R., Lo, Roger S., McBride, William H., Segura, Tatiana, Ribas, Antoni
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974650/
https://ncbi.nlm.nih.gov/pubmed/27476449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12348
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