Structure of Complement C3(H(2)O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

The slow but spontaneous and ubiquitous formation of C3(H(2)O), the hydrolytic and conformationally rearranged product of C3, initiates antibody-independent activation of the complement system that is a key first line of antimicrobial defense. The structure of C3(H(2)O) has not been determined. Here...

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Библиографические подробности
Опубликовано в: :Mol Cell Proteomics
Главные авторы: Chen, Zhuo A., Pellarin, Riccardo, Fischer, Lutz, Sali, Andrej, Nilges, Michael, Barlow, Paul N., Rappsilber, Juri
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Biochemistry and Molecular Biology 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974347/
https://ncbi.nlm.nih.gov/pubmed/27250206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.056473
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