AP-1 Inhibition by SR 11302 Protects Human Hepatoma HepG2 Cells from Bile Acid-Induced Cytotoxicity by Restoring the NOS-3 Expression

The harmful effects of bile acid accumulation occurring during cholestatic liver diseases have been associated with oxidative stress increase and endothelial nitric oxide synthase (NOS-3) expression decrease in liver cells. We have previously reported that glycochenodeoxycholic acid (GCDCA) down-reg...

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Veröffentlicht in:PLoS One
Hauptverfasser: González-Rubio, Sandra, Linares, Clara I., Aguilar-Melero, Patricia, Rodríguez-Perálvarez, Manuel, Montero-Álvarez, José L., de la Mata, Manuel, Ferrín, Gustavo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973998/
https://ncbi.nlm.nih.gov/pubmed/27490694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160525
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