Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase

Phase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging tha...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Sánchez-Gómez, Francisco J., Díez-Dacal, Beatriz, García-Martín, Elena, Agúndez, José A. G., Pajares, María A., Pérez-Sala, Dolores
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973429/
https://ncbi.nlm.nih.gov/pubmed/27540362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00237
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