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Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

AIM: Accumulating evidence shows that lipopolysaccharides (LPS) derived from gut gram-negative bacteria can be absorbed, leading to endotoxemia that triggers systemic inflammation and insulin resistance. In this study we examined whether metformin attenuated endotoxemia, thus improving insulin signa...

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Bibliografische gegevens
Gepubliceerd in:Acta Pharmacol Sin
Hoofdauteurs: Zhou, Zi-yu, Ren, Li-wei, Zhan, Ping, Yang, Han-yan, Chai, Dan-dan, Yu, Zhi-wen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973377/
https://ncbi.nlm.nih.gov/pubmed/27180982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.21
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