Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6

Cereblon (CRBN) is a substrate receptor protein for the CRL4A E3 ubiquitin ligase complex. In this study, we report on a new regulatory role of CRBN in TLR4 signaling. CRBN overexpression leads to suppression of NF-κB activation and production of pro-inflammatory cytokines including IL-6 and IL-1β i...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Min, Yoon, Wi, Sae Mi, Kang, Jung-Ah, Yang, Taewoo, Park, Chul-Seung, Park, Sung-Gyoo, Chung, Sungkwon, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973362/
https://ncbi.nlm.nih.gov/pubmed/27468689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.226
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