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Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state

A-kinase anchoring proteins (AKAPs) are a family of proteins that provide spatiotemporal resolution of protein kinase A (PKA) phosphorylation. In the myocardium, PKA and AKAP18γ/δ are found in complex with sarcoendoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) and phospholamban (PLB). This macromolecul...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Bjerregaard-Andersen, Kaare, Østensen, Ellen, Scott, John D., Taskén, Kjetil, Morth, Jens Preben
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973299/
https://ncbi.nlm.nih.gov/pubmed/27487922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16010189
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