Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo

BACKGROUND: Clinical options for patients harbouring advanced/recurrent uterine serous carcinoma (USC), an aggressive variant of endometrial tumour, are very limited. Next-generation sequencing (NGS) data recently demonstrated that cyclin E1 (CCNE1) gene amplification and pik3ca driver mutations are...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Cocco, Emiliano, Lopez, Salvatore, Black, Jonathan, Bellone, Stefania, Bonazzoli, Elena, Predolini, Federica, Ferrari, Francesca, Schwab, Carlton L, Menderes, Gulden, Zammataro, Luca, Buza, Natalia, Hui, Pei, Wong, Serena, Zhao, Siming, Bai, Yalai, Rimm, David L, Ratner, Elena, Litkouhi, Babak, Silasi, Dan-Arin, Azodi, Masoud, Schwartz, Peter E, Santin, Alessandro D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973158/
https://ncbi.nlm.nih.gov/pubmed/27351214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.198
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