Model of the ankyrin and SOCS box protein, ASB9, E3 ligase reveals a mechanism for dynamic ubiquitin transfer

Cullin-RING E3 Ligases (CRLs) are elongated and bowed protein complexes that transfer ubiquitin over 60 Å to proteins targeted for proteasome degradation. One such CRL contains the ankyrin repeat and SOCS box protein 9 (ASB9), which binds to and partially inhibits creatine kinase (CK). While current...

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Publicado en:Structure
Main Authors: Schiffer, Jamie M., Malmstrom, Robert D., Parnell, Jonathan, Ramirez-Sarmiento, Cesar, Reyes, Javiera, Amaro, Rommie E., Komives, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972691/
https://ncbi.nlm.nih.gov/pubmed/27396830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.05.016
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