Distinct myeloid progenitor differentiation pathways identified through single cell RNA sequencing

According to current models for hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs; Lin(−)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs; Lin(−)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage commitment pathways from hematopoie...

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Udgivet i:Nat Immunol
Main Authors: Drissen, Roy, Buza-Vidas, Natalija, Woll, Petter, Thongjuea, Supat, Gambardella, Adriana, Giustacchini, Alice, Mancini, Elena, Zriwil, Alya, Lutteropp, Michael, Grover, Amit, Mead, Adam, Sitnicka, Ewa, Jacobsen, Sten Eirik W., Nerlov, Claus
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972405/
https://ncbi.nlm.nih.gov/pubmed/27043410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3412
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