Temporal Dynamics of CD8(+) T Cell Effector Responses during Primary HIV Infection

The loss of HIV-specific CD8(+) T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8(+) T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection, is unclear. Here, we assessed CD8(+) T cell f...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Demers, Korey R., Makedonas, George, Buggert, Marcus, Eller, Michael A., Ratcliffe, Sarah J., Goonetilleke, Nilu, Li, Chris K., Eller, Leigh Anne, Rono, Kathleen, Maganga, Lucas, Nitayaphan, Sorachai, Kibuuka, Hannah, Routy, Jean-Pierre, Slifka, Mark K., Haynes, Barton F., McMichael, Andrew J., Bernard, Nicole F., Robb, Merlin L., Betts, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972399/
https://ncbi.nlm.nih.gov/pubmed/27486665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005805
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