Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy

Diabetic peripheral neuropathy (DPN) is a major diabetic complication. Previously, we showed that hyperglycemia induces the appearance of proinsulin (PI)-producing bone marrow-derived cells (PI-BMDCs), which fuse with dorsal root ganglion neurons, causing apoptosis, nerve dysfunction, and DPN. In th...

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Bibliografiske detaljer
Udgivet i:Am J Physiol Endocrinol Metab
Main Authors: Urabe, Hiroshi, Terashima, Tomoya, Kojima, Hideto, Chan, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2015
Fag:
Translational Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971812/
https://ncbi.nlm.nih.gov/pubmed/26695138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00381.2015
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