Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer

BACKGROUND: The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted therapies. The oncogenic signaling pathways...

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發表在:BMC Cancer
Main Authors: She, Qing-Bai, Gruvberger-Saal, Sofia K., Maurer, Matthew, Chen, Yilun, Jumppanen, Mervi, Su, Tao, Dendy, Meaghan, Lau, Ying-Ka Ingar, Memeo, Lorenzo, Horlings, Hugo M., van de Vijver, Marc J., Isola, Jorma, Hibshoosh, Hanina, Rosen, Neal, Parsons, Ramon, Saal, Lao H.
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971667/
https://ncbi.nlm.nih.gov/pubmed/27484095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2609-2
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