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Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells.

The alpha-adrenergic agonist oxymetazoline increased Na+,K(+)-ATPase activity of single proximal convoluted tubules dissected from rat kidney. Activation of the enzyme by oxymetazoline was prevented by either the alpha 1-adrenergic antagonist prazosin or the alpha 2-adrenergic antagonist yohimbine a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Aperia, A, Ibarra, F, Svensson, L B, Klee, C, Greengard, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49716/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1380157/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7394
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