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A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

An assay that selectively amplifies a specific deletion of the mitochondrial genome has been used to study the extent of the deletion's accumulation in a variety of human tissues. The deletion occurs at much higher levels in nervous and muscle tissues than in all other tissues studied. The vari...

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Autors principals: Cortopassi, G A, Shibata, D, Soong, N W, Arnheim, N
Format: Artigo
Idioma:Inglês
Publicat: 1992
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC49711/
https://ncbi.nlm.nih.gov/pubmed/1502147
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