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Solvent and Temperature Probes of the Long-Range Electron-Transfer Step in Tyramine β-Monooxygenase: Demonstration of a Long-Range Proton-Coupled Electron-Transfer Mechanism

[Image: see text] Tyramine β-monooxygenase (TβM) belongs to a family of physiologically important dinuclear copper monooxygenases that function with a solvent-exposed active site. To accomplish each enzymatic turnover, an electron transfer (ET) must occur between two solvent-separated copper centers...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Zhu, Hui, Sommerhalter, Monika, Nguy, Andy K. L., Klinman, Judith P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970857/
https://ncbi.nlm.nih.gov/pubmed/25919134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja512388n
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