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The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants

Genome-wide association studies (GWAS) have long relied on proposed statistical significance thresholds to be able to differentiate true positives from false positives. Although the genome-wide significance P-value threshold of 5 × 10(−8) has become a standard for common-variant GWAS, it has not bee...

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Podrobná bibliografie
Vydáno v:Eur J Hum Genet
Hlavní autoři: Fadista, João, Manning, Alisa K, Florez, Jose C, Groop, Leif
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970684/
https://ncbi.nlm.nih.gov/pubmed/26733288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2015.269
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