Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model

Agonist-activated G protein-coupled receptors (GPCRs) interact with GDP-bound G protein heterotrimers (Gαβγ) promoting GDP/GTP exchange, which results in dissociation of Gα from the receptor and Gβγ. The GTPase activity of Gα hydrolyzes GTP to GDP, and the GDP-bound Gα interacts with Gβγ, forming a...

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Pubblicato in:PLoS One
Autori principali: Kim, Min Hyeok, Kim, Young Jin, Kim, Hee Ryung, Jeon, Tae-Joon, Choi, Jae Boong, Chung, Ka Young, Kim, Moon Ki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970668/
https://ncbi.nlm.nih.gov/pubmed/27483005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159528
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