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Carboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product.

The rat neu oncogene encodes a constitutively activated growth factor receptor/transmembrane tyrosine kinase, p185Tneu, that is structurally similar to yet distinct from the epidermal growth factor receptor. To explore the role of the carboxyl-terminal region and of putative autophosphorylation site...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Mikami, Y, Davis, J G, Dobashi, K, Dougall, W C, Myers, J N, Brown, V I, Greene, M I
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49704/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1354355/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7335
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