Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

BACKGROUND: The mouse strain BALB/c deficient in IL-1 receptor antagonist protein (Il-1ra) develops spontaneous arthritis disease (SAD) while the strain DBA/1 IL1rn(-/-) with the same deficiency does not. Previously, we mapped a QTL on chromosome 1 for SAD and then developed a congenic mouse strain...

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Pubblicato in:BMC Immunol
Autori principali: Liu, Xiaoyun, Jiao, Yan, Cao, Yanhong, Deng, Nan, Ma, Yonghui, Hasty, Karen A., Kang, Andrew, Chen, Hong, Stuart, John M., Gu, Weikuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970213/
https://ncbi.nlm.nih.gov/pubmed/27480124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-016-0163-y
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